Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). NexGard is available in four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Keep NexGard in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Afoxolaner … At 72 hours post-infestation, NexGard demonstrated >97% effectiveness against Amblyomma americanum for 30 days. Shop WalmartPetRx.com for Nexgard for Dogs and Puppies and all of your other pet medications. NexGard (afoxolaner) is for use in dogs only. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 26-29 • In dogs with Sarcoptes scabiei var canis, 2 doses of afoxolaner (on days 0 and 28) or sarolaner (on days 0 and 30) or a single dose … NexGard can be administered with or without food. Use with caution in dogs … However, one thing to note is that some dogs with issues like muscle tremors, seizures and ataxia may be adversely affected by afoxolaner… The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Each chewable is formulated to provide … QUALITATIVE AND QUANTITATIVE COMPOSITION. One tablet dose should be given once a month depending on dog… Each chewable tablet contains: Active substance: NexGard Afoxolaner (mg) chewable tablets for dogs 2–4 kg 11.3 chewable tablets for dogs >4–10 kg 28.3 chewable tablets for dogs >10–25 kg 68 chewable tablets for dogs >25–50 kg … Afoxolaner kills adult fleas as well as adult ticks. All Rights Reserved. After it is ingested, afoxolaner is slowly expelled from your dog's body through the metabolism, which is how NexGard remains effective for a full 30 days. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merial at 1-888-637-4251 or www.nexgardfordogs.com. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. The following adverse events reported for dogs are listed in decreasing order of reporting frequency for NexGard: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), allergic reactions (including hives, swelling), and tremors. Background: A multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. The dog remained enrolled and completed the study. 1Number of dogs in the afoxolaner treatment group with the identified abnormality. Terms of Use | Copyright © 2021. Select one or more newsletters to continue. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. Commercial chewable tablets of different strength were combined to deliver doses as close as possible to the minimum effective dose of 2.5mg afoxolaner plus 0.5mg milbemycin oxime per kg body weight. Afoxolaner was formulated as a nonmeat‐based chewable dosing form designed for monthly oral administration and was developed and registered as NexGard ®, the first product to effectively control both fleas and ticks on dogs … In a 90-day field study, 415 dogs were administered afoxolaner … A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. Copyright © 2021 Animalytix LLC. When a flea or tick bites your dog, this drug, like fluralaner, kills the arthropod very quickly. 2. In a well-controlled laboratory study, NexGard began to kill fleas four hours after initial administration and demonstrated >99% effectiveness at eight hours. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Use with caution in dogs with a history of seizures or neurologic disorders (see Adverse Reactions and Post-Approval Experience). Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. Dogs in both the treated and control groups that were infested with fleas on Day -1 generated flea eggs at 12- and 24-hours post-treatment (0-11 eggs and 1-17 eggs in the NexGard treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12- and 24-hours, respectively). ... and has been shown to be safe at up to 5 times the recommended dose. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Not for use in humans. The most frequently reported adverse reaction was vomiting. It can be used for the treatment strategy of flea allergy dermatitis. NEXGARD- afoxolaner tablet, chewableFrontline Vet Labs. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. In well-controlled laboratory studies, NexGard demonstrated >97% effectiveness against Dermacentor variabilis, >94% effectiveness against Ixodes scapularis, and >93% effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. In case of accidental ingestion, contact a physician immediately. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA. Administer the appropriate combination of chewables. 2Number of dogs in the control group with the identified abnormality. This dog experienced a third seizure one week after receiving the third dose. Methods: Client-owned dogs… In a margin of safety study, NexGard was administered orally to 8 to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. … The dog remained enrolled and completed the study. Keep this and all drugs out of the reach of children. In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. Every effort has been made to ensure the accuracy of the NexGard information published above. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F). Treatment with NexGard may begin at any time of the year. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for NexGard. The following adverse events are based on post-approval adverse drug experience reporting. In two separate, well-controlled laboratory studies, NexGard was effective at preventing Borrelia burgdorferi infections after dogs were infested with Ixodes scapularis vector ticks 28 days post-treatment. Sarcoptic mange or demodectic mange and independent information on more than 24,000 prescription drugs, contact physician! 6 beef-flavored chewables 's central repository of drug labels and package inserts under the Structured product Labeling.! 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