In case of allergic reaction, contact a physician. Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. The vet told us he could not rule out the collars from causing these symptoms in our beloved pets Danny & Dominic. K9 ADVANTAGE II is a follow-up product for BAYER's ADVANTAGE, its first imidacloprid once-a-month spot-on for dogs and cats against fleas.. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.). I would also like to use Advantage Multi which is a topical and contains IMIDACLOPRID and MOXIDECTIN. Hypersensitivity reactions were not seen in the 5X treatment group. He basicly said it's like hitting the lottery it's possible the collars may have caused it. The 10 1/2 yr old Danny was lethargic early in the day he perked up in the mid afternoon & ate chicken & pasta while Dominic remained lethargic. When used on crops, Imidacloprid is taken up by plant roots and into the plant vascular system, where insects ingest it along with the plant fluids. Small dogs can also be at risk of developing toxicity to imidacloprid. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. We came back at 11am with Dominic who remained lethargic & still was not eating. Other Names Imidacloprid, benzyl alcohol This SDS covers the following six products: Advantage for Kittens and Small Cats up to 4kg Advantage for Cats over 4kg Advantage for Puppies and Small Dogs up to 4 kg Advantage for Dogs 4-10kg Advantage for Dogs 10-25kg Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. In both groups, there were more adverse reactions to Advantage Multi for Dogs following the first treatment than the second treatment. My wife & i truly believe your collar killed my prescious dog Danny& has almost caused Dominic to die twice on 6/8/19 & 6/9/19. Advantus Soft Chews contain imidacloprid, and begin to kill fleas within 1 hour of treatment. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. My wife & i were actually force feeding him by spoon he was throwing it up meds & food then the water. Your veterinarian will continue to monitor your dog’s progress and perform testing to ensure that no long term damage has been done to your dog. For dogs, the corresponding “Advocate for dog” product, which contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used. Do not allow the dog to lick any of the application sites for 30 minutes. 2. Administered about every 4 weeks, K9 ADVANTIX II controls established flea infestations and prevents flea populations to develop in the pets environment, but only if all the dogs and cats in the same household are treated against fleas. Once your veterinarian has diagnosed imidacloprid toxicity in your dog, your veterinarian will discuss treatment options. Laboratory Safely Study in Heartworm-Positive Dogs: Advantage Multi for Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. The dog should be standing for application. The Safety Data Sheet (SDS) provides additional occupational safety information. Keep out of the reach of children. Imidacloprid is a neonicotinoid insecticide, approved for use in the United States by the Environmental Protection Agency in 1994. Imidacloprid and Flumethrin, ingredients in Seresto®, is a flea and tick collar that provides protection for eight months to dogs and cats. Then excessive salivation can occur as well as gastrointestinal upset and muscle weakness. Also, I had to put symptoms etc. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-O- Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino) milbemycin B. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. I am looking for only topical preventatives for my beagles. If contact with skin or clothing occurs, take off contaminated clothing. He was laying down in our camper kitchen floor as we patted him to bring him out of it. should be treated with the appropriate combination of Advantage Multi for Dogs tubes. Causes eye irritation. 4.4 Special warnings for each target species . Dogs with sensitive skin are also prone to developing toxicity to imidacloprid. Imidacloprid is, for example, present as a main (or the sole) active ingredient in concentrations between five and ten percent in three out of the four most widely used flea treatment and preventative topical treatments for dogs in the United States; these manufacturers claim an effective killing persistence of at least four weeks. I bought 4 collars for my 4 dogs on 5/6/19 at the Abington animal hospital in Abington Ma. This drug combination is produced by Bayer is labeled to prevent fleas, heartworms, gastrointestinal parasites (in dogs) and ear mites (in cats). On the morning of Saturday 6/8/19 my 10 1/2 yr old Danny had another seizure with coughing. i'm just hoping there's no neurologogical damage IMIDACLOPRID can cause. The following adverse events in dogs are listed in decreasing order of reporting frequency: depression/lethargy, vomiting, pruritus, diarrhea, anorexia, hyperactivity, ataxia, trembling, hypersalivation, application site reactions (alopecia, pruritus, lesions, and erythema), seizures, and anaphylaxis/anaphylactic reactions (hives, urticaria, facial swelling, edema of the head). Copyright © 2021 Animalytix LLC. More severe symptoms that seem to affect your dog’s neurological system will most likely require hospitalization and supportive care. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Every effort has been made to ensure the accuracy of the Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs information published above. I am writing this letter telling you at Bayer my experience with your Seresto collars. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application of Advantage Multi for Dogs. these cavachons are the most loving & happy dogs i have ever had & now they're gone over a chemical collar that can kill your dog by the pesticides in them. Box 390, Shawnee Mission, Kansas 66201 U.S.A. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. One dog exhibited shaking (nervousness) 1 hour post-dosing. For consumer questions call 1-800-255-6826. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Once-a-month topical solution for the prevention of heartworm disease, the treatment of circulating microfilariae, kills adult fleas, is indicated for the treatment of flea infestations, the treatment and control of sarcoptic mange, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. *Wag! The proper application of imidacloprid is important to prevent your dog from having a reaction, closely follow the directions and if you are unsure about a product consult your veterinarian. (See ADVERSE REACTIONS and ANIMAL SAFETY - Safety Study in Heartworm-Positive Dogs.). For dogs weighing 20 lbs. Şeker pancarı: Şeker pancarı tohumlarının rutubete olan duyarlılığı nedeni ile ve hassas bir ilaçlama yapabil- mek için profesyonel ilaçlama düzenleri olan tohum işleme ve ilaçlama fabrikalarında uygulanacak ilaç karışımı hacmi, ekipman tipine, karışımına giren diğer maddelere ve kurutma imkanlarına bağlıdır. We brought Danny's body back to the vet at the Country Vet clinic that morning when they opened. Avoid contact with skin. Imidacloprid is generally safe to use on dogs over seven weeks of age and any size. Please refer to section 4.5. The signs resolved without intervention by day 10 post-application. COMMENTS. Dr Simpson's autopsy did not show any abnormalities of any of Danny's organs kidneys liver, lungs, stomach. Dr Simpson still could not find a reason for all that had happened to our cavachons & the seizures that they had 15 hours apart from each other. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. the only thing we did different with our dogs is to get them these Seresto collars. Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. LD50 acute, rats, p.o. Fleas in your dog's environment can re-infest your dog, therefore you may need to treat with Advantus more than one time. The moxidectin may be used as a direct prevention for heartworm and is also a treatment for microfilariae in dogs; imidacloprid is a mosquito repellent which will also prevent heartworm. They will also want to know if any sprays or other topical flea treatments have recently been used on your dog. The dogs ranged in age from 2 months to 12.5 years and ranged in weight from 3 to 231.5 pounds. *Trans Z-1/trans Z-2 ratio: max 66% trans Z-1 ... Insert end of the collar through the buckle. these were my best dogs ever Danny got me thru 10 surgeries over a 9 year period with Dom Dom also there for a few. We found that every symptom both our little dogs had can be caused by this pesticide that you use in these collars. Imidacloprid is a systemic insecticide manufactured by Bayer Cropscience for the control of turf, crop, and structural pests. Harmful if swallowed. Effectiveness against circulating D. immitis microfilariae was > 90% at five of six sites; however, one site had an effectiveness of 73.3%. When diagnosing imidacloprid toxicity, your veterinarian will first take a thorough medical history and ask you about the symptoms that you have seen. Your veterinarian will order your dog be thoroughly bathed to remove as much of the toxins from their coat and skin. On Wednesday 6/13/19 Dominic finally ate some without us feeding him. Turn the cap over and push the other end of cap onto the tip of the tube. If eye irritation develops or persists, contact a physician. We looked up the ingredients of the Seresto collars espescially the pesticide used by the name IMIDACLOPRID. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. Bayer HealthCare LLC, Animal Health Division, P.O. The spot-on was applied every 2 weeks. The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Add to cart ... Flumethrin* – 4.5%.Imidacloprid – 10.0%.Other Ingredients – 85.5%.Total – 100.0%. If a dose is missed and a 30-day interval between doses is exceeded, administer Advantage Multi for Dogs immediately and resume the monthly dosing schedule. Imidacloprid binds to the acetylcholine receptor on the postsynaptic part of the nerve cells of the flea; this will cause paralysis and death of the flea. My Dominic has showed some improvement but is still far from the active & playful dog he was before his seizure on 6/6/19. Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease. He has been eating a little better each day but has continued to vomit on occassion. he also gave us pills of both meds to give him for 5 days. Imidacloprid toxicity in dogs is rare, but can occur especially if your dog licks the imidacloprid. I also don't know how much either dog weighs so it is difficult for me to comment on whether it is a problem. I truly believe it killed them both & feel the need to warn all you pet owners. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. He had some thickening of the arteris around his heart which may have caused the cough he had along with the hi pollen this spring. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. In a field safety and effectiveness study, Advantage Multi for Dogs was administered to 92 client-owned dogs with sarcoptic mange. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. Acute Toxicity and Tolerance of Imidacloprid. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. Use in dogs and puppies at least 10 weeks old and 4 pounds body weight. Subchronic exposure of dogs toimidacloprid resulted in severe tremors. Dom Dom as we called him was the black & white dog. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. All dogs were hospitalized for a minimum of 12 hours following each treatment. he did blood work & iv fluids to hydrate him. Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Diarrhea / Itching / Muscle Tremors / Shaking / Vomiting / Weakness. This will help determine the exact cause of your dog’s ailment and if there has been internal damage done. Adverse reactions in dogs treated with Advantage Multi for Dogs included hematochezia, diarrhea, vomiting, lethargy, inappetence, and pyoderma. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The trademarks for imidacloprid as a termiticide are Hachikusan® (Japan), Premise® (USA, Australia, Asia, world-wide). We have spent $285 for the 4 collars we bought our dogs that wore them for 1 month to the day 5/6/19 - 6/6/19. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. The following adverse events are based on post-approval adverse drug experience reporting. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. Following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride, the following adverse reactions were observed: Dogs Treated with Advantage Multi for Dogs Only n=106, Dogs Treated with Advantage Multi for Dogs + Melarsomine n=108. It is best to only apply imidacloprid to healthy dogs that are over seven weeks old. Call a poison control center or physician for treatment advice. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. Product Use Spot-on insecticide for flea control in dogs and cats. Bayer Seresto 8 Month Flea & Tick Prevention Collar for Large Dogs quantity. We comply with the HONcode standard for trustworthy health information -, Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs Indications, Warnings and cautions for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs, Direction and dosage information for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. The Dr took him in the back room to do an autopsy after they closed at noon. Do not let this product get in your dog’s mouth or eyes. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. We took Dominic back to the vet on Monday 6/10/19 where he received more iv fluids & shots of prednisone & an anti neahsea to help his appetite out. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. These include plant hoppers, aphids, termites, Colorado beetles, fleas, white grups, craneflies, crickets and ants. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. Twist the cap to break the seal and then remove cap from the tube. My dogs are always with us they got into nothing that might cause these problems what so ever. Treatment with an approved adulticide therapy is recommended because Advantage Multi for Dogs is not effective for the treatment of adult D. immitis. One dog showed signs of treatment site irritation after application. Your veterinarian will be searching for the cause and also how to quickly treat your dog to stop the toxic poisoning. Imidacloprid is an neonicotinoid agricultural insecticide used to control sucking insects, termites, soil insects, and fleas on pets. If swallowed, call poison control center or physician immediately for treatment advice. Advantage Multi for Dogs is not effective against adult D. immitis. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Now my Danny is dead & as i write this on 6/17/19. The study was a parallel group design, single centre, randomised, n … All dogs received Advantage Multi for Dogs on Study Days 0 and 28; 108 dogs also received melarsomine dihydrochloride on Study Days - 14, 14, and 15. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. On Thursday 6/6/19 @ 3am my 5 yr old Cavachon Dominic had a seizure, we immediately took the collar off him along with the Danny our other Cavachon & had our son at home take the collars off our other 2 dogs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 15 Imidacloprid is used with pyriproxyfen in topical spot-on products to kill all life stages of fleas on dogs and cats and to prevent and control lice infestations on dogs. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. Part the hair on the back of the dog between the shoulder blades until the skin is visible. 131 mg/kg LD50 acute, rats, dermal >5000 mg/kg As a general rule, dogs and cats tolerate imidacloprid very well. Since they each act differently and effectively against fleas, why isn't a product available with fipronil AND imidacloprid? Company: Bayer Animal Health advantus™ is a flavored soft chew for dogs and puppies 10 weeks of age and older and weighing 4 pounds or greater. later that night Dominic had another episode where he fell over & vomited & pooped all over our campers deck. People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. Imidacloprid is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. Is it safe to use both topicals. At 5X, one dog was observed vomiting three hours after the second treatment. In severe tremors down then back up the ingredients of the toxins & started wrenching back forth. Run off the side of the application sites for two ( 2 ) hours after application cap onto tip. 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